When weakened by CKD, this filtering process becomes less effective which can result in high levels of urea and creatinine in the blood that lead to other health problems such as anemia or malnutrition.

Normally this disease is of chronic origin and usually has a slow gradual onset without any symptoms except a slight feeling of being unwell at a general level. It is a progressive loss of kidney function where the kidney is allowing the proteins, Red blood cells to be lost in urine as the kidney is losing its capacity of filtration and also the waste products such as urea, nitrogenous waste are not getting eliminated from our body and their levels are rising in the blood.

It is usually found in patients who have long-standing uncontrolled Diabetes Mellitus, Hereditary Hypertension (uncontrolled High Blood pressure), Anemia, and Heart Disease.

Chronic Kidney Disease is the End Stage of Renal function or End stage of Kidney Disease where the patient requires an artificial filtration system (Dialysis) on a regular basis as the kidney has lost the ability to do so.

A low GFR and high Creatinine levels are often diagnostic of chronic kidney disease